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Beilstein J. Org. Chem. 2018, 14, 583–592, doi:10.3762/bjoc.14.45
Graphical Abstract
Figure 1: Commercially available antimalarial drugs.
Scheme 1: Current batch syntheses of the key intermediate 5-(ethyl(2-hydroxyethyl)amino)pentan-2-one (6).
Scheme 2: Retrosynthetic strategy to hydroxychloroquine (1).
Scheme 3: Schematic representation for continuous in-line extraction of 10.
Scheme 4: Optimization of the flow process for the synthesis of 12.
Beilstein J. Org. Chem. 2014, 10, 3111–3121, doi:10.3762/bjoc.10.328
Figure 1: General structures of several D-glucose and D-glucosamine derivatives.
Scheme 1: Synthesis of amide and urea derivatives of the headgroup 3.
Figure 2: a) A translucent/opaque gel formed by compound 19 in EtOH/H2O (1:2) at 1.3 mg/mL; b) a gel formed b...
Figure 3: The rheological measurements of the gels formed by amide 11 (EtOH/H2O, 1:2) at 5.4 mg/mL, urea 16 (...
Figure 4: The optical micrographs of the wet gels formed by several amides. a) A gel formed by compound 8 in ...
Figure 5: The optical micrographs of the wet gel samples formed by several ureas. a) Compound 19 in DMSO/H2O ...
Figure 6: Stability test results under acidic conditions. a) A gel formed by compound 23 in DMSO/H2O (1:2) at...
Figure 7: Release of naproxen sodium from the gel formed by compound 16 to the aqueous phase.
Figure 8: Naproxen release study from the gel formed by compound 16 in the presence of acid.